uploads///Chart  NMDA

What Are Sage Therapeutics’ Receptor-Based Products?


Dec. 4 2020, Updated 10:53 a.m. ET

NMDA products

Sage Therapeutics (SAGE) is focused on the development of products for the treatment of life-threatening central nervous system (or CNS) disorders. One of the products under development, SAGE-718, is based on the NMDA receptor program.

The above chart shows the details of the product under development for the NMDA Receptor program.

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NMDA receptor

Overall, there are three types of ionotropic glutamate receptors:

  • NMDA (or N-methyl-D-aspartate) receptor
  • AMPA (or alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptor
  • kainic acid receptor


Sage Therapeutics has developed SAGE 718, a product that targets the NMDA Receptor. SAGE-718 is the first compound to be developed by Sage Therapeutics outside the GABA receptor program.

SAGE-718 is an oxysterol-based positive allosteric modulator of the NMDA receptor. The drug SAGE-718 is under Phase I clinical trials that are evaluating the drug as a treatment of cerebro-sterol deficit disorders, anti-NMDA receptor encephalitis, and other indications that involve NMDA receptor hypofunction.

SAGE-718 was developed as a once-daily dosage compound. The phase I single ascending dose (or SAD) trial is a double-blind placebo-controlled study to evaluate the safety, tolerance, and pharmacokinetics as well as pharmacodynamics effects of SAGE-718 when administered orally to adults once a day. The results of this trial are expected in the second half of 2017.

To divest the company-specific risks, investors can consider ETFs like the PowerShares DWA Healthcare Momentum ETF (PTH), which holds 1.4% of its total assets in Sage Therapeutics (SAGE). PTH also holds 3.5% in UnitedHealth Group (UNH), 3.2% in Becton Dickinson (BDX), and 2.6% in Aetna (AET).


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