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Bone Health and Cancer Treatments: Amgen’s Key Growth Areas


Jun. 30 2019, Updated 10:28 a.m. ET

Bone health trends

Amgen’s (AMGN) leading bone health drug, Prolia, reported revenue of $592 million in the first quarter, a YoY (year-over-year) rise of 20% driven by 17% YoY volume growth. The drug is approved for postmenopausal women with osteoporosis and a high risk of fracture, for cancer-treatment-induced bone loss, for bone loss in men with osteoporosis and a high risk of fracture, and for glucocorticoid-induced osteoporosis. According to Amgen’s first-quarter earnings call, owing to its six-month dosing interval, Prolia’s sales in the first and third quarters are generally lower than those in the second and fourth quarters of the year.

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On April 9, the FDA approved Evenity, a drug that’s capable of aiding bone formation while reducing bone loss, to treat osteoporosis in postmenopausal women who are at a high risk of fracture. The drug was commercially launched in the US with a list price of $21,900 for the full treatment course of 12 doses. Evenity is also approved in Japan and is being launched there via a joint venture with Astellas Pharma.

Oncology trends

In the first quarter, Amgen’s oncology drugs Xgeva, Nplate, Vectibix, Kyprolis, Imlygic, and Blincyto reported a combined $1.2 billion in revenue, up 8% YoY.

In the first quarter, Kyprolis, Amgen’s multiple myeloma drug, reported revenue of $154 million, a YoY rise of 10%. The drug’s once-a-week dosing regimen accounts for almost 20% of its usage in the US. Amgen’s Xgeva reported revenue of $471 million, a rise of 6% YoY.

Blincyto’s sales rose 41% YoY to $69 million in the first quarter. According to its first-quarter earnings call, Amgen is also studying Blincyto in combination with PD-1 inhibitors in various indications.

One of the highly watched investigational therapies in Amgen’s R&D pipeline is AMG 510, the first KRASG12C Inhibitor in the clinical testing phase. The company presented promising data from its Phase 1 trial evaluating this therapy in non-small cell lung cancer and colorectal cancer indications at an American Society of Clinical Oncology meeting.


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