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Cabometyx Is Expected to Witness a Robust Revenue Rise in 2018

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Cabometyx growth trends

In the first quarter, Exelixis’s (EXEL) Cabometyx witnessed more than a 20% sequential rise in prescription volume driven by both new patient starts and a robust rise in the total number of patients on the therapy.

According to a report, ~295,000 people across the world are diagnosed with kidney cancer every year, while 134,000 kidney cancer patients die every year. According to the American Cancer Society’s Cancer Facts & Figures 2018, the annual incidence of kidney cancer in the United States is ~65,000, while the annual death toll of the disease is 15,000. Another report estimates that almost 70%–75% of renal cell cancer (or RCC) patients suffer from clear cell RCC.

In this context, the American Cancer Society’s Cancer Facts & Figures 2015 has estimated the total number of RCC patients eligible for Cabometyx therapy in second-line or later settings to be ~37,000 globally. Of those eligible, 17,000 patients are in the United States.

Another report from 2014 has estimated the total number of RCC patients eligible for first-line Cabometyx therapy to be ~32,000 globally, of whom 14,000 are in the United States.

These statistics highlight the level of underserved market opportunity for Cabometyx in the RCC space.

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Label expansion strategy

The capsule formulation of cabozantinib, Cometriq, is approved in a medullary thyroid cancer indication, while the tablet formulation, Cabometyx, is approved in all lines of treatment for RCC.

On March 15, Exelixis filed a supplemental new drug application (or sNDA) to the FDA seeking approval for Cabometyx in second-line plus advanced hepatocellular carcinoma (or HCC) indications.

On March 28, Ipsen announced that the European Medicines Agency (or EMA) had validated its application for expanding Cabometyx’s label in second-line plus HCC indications.

Cabometyx is thus expected to enable Exelixis to compete effectively with multiple oncology players such as Pfizer (PFE), Novartis (NVS), and Bristol-Myers Squibb (BMY).

In the next article, we’ll discuss label expansion programs for Cabometyx in greater detail.

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