uploads///Graph

Incyte Advances R&D Strategy with Multiple Partnerships

By

Apr. 12 2018, Updated 10:31 a.m. ET

Collaboration with Agenus

In January 2015, Incyte (INCY) entered an antibody discovery collaboration with Agenus (AGEN), which was later amended in February 2017. As per the amended agreement, the ongoing research programs for the development of checkpoint modulator antibodies targeted at GITR and OX40 have been converted from co-funded ones to being fully funded by Incyte. Additionally, the profit-sharing arrangement for these research programs has been converted into royalty-bearing programs. Currently, Incyte is responsible for the worldwide development and commercialization of these investigational therapies, while Agenus will be receiving 15% royalty on net sales of these therapies in case either one or both are approved. Based on the amended agreement, Incyte was to pay $80 million as milestone payments, which consist of $20 million as accelerated clinical development milestones and $60 million as equity investment in Agenus.

Article continues below advertisement

The above diagram explains the key characteristics of Agenus’s Retrocyte Display antibody discovery platform. The amended agreement also removed two undisclosed targets from the profit-sharing arrangement. The remaining two ongoing programs involving checkpoint modulator antibodies targeting LAG-3 and TIM-3 are royalty-bearing arrangements with Incyte responsible for worldwide development and commercialization and Agenus earning royalties at tiered rates in the range of 6% to 12%. In November 2015, both companies also started working on an additional three targets under the collaboration.

Other collaborations

In December 2016, Incyte entered a collaboration with Merus (MRUS) and secured exclusive rights for the latter’s 11 bispecific antibody research programs, which are being developed on Merus’s Biclonics platform.

In January 2018, Incyte entered a target discovery and research collaboration with Syros Pharmaceuticals (SYRS). Based on the agreement, Syros will identify novel targets in myeloproliferative neoplasms indications using its gene control platform, while Incyte will enjoy the option to obtain exclusive worldwide development and commercialization rights for seven of the validated targets.

Advertisement

More From Market Realist

  • Businesswoman looking out a window
    Company & Industry Overviews
    Shifting Focus: Three Women Investing Funds in 2021
  • Aol logo on office building,
    Company & Industry Overviews
    What We Know About Apollo Global Management, New Owners of AOL and Yahoo
  • Chick-fil-A sign
    Company & Industry Overviews
    Why It Only Costs $10K to Own a Chick-fil-A Location
  • Beyond Meat Burger 3.0
    Company & Industry Overviews
    How Is Beyond Burger 3.0 Different and Will It Bring BYND Stock Up?
  • CONNECT with Market Realist
  • Link to Facebook
  • Link to Twitter
  • Link to Instagram
  • Link to Email Subscribe
Market Realist Logo
Do Not Sell My Personal Information

© Copyright 2021 Market Realist. Market Realist is a registered trademark. All Rights Reserved. People may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.