Neuroendocrine tumors

AbbVie (ABBV) aims to position its investigational therapy Rova-T (rovalpituzumab tesirine) as a standard of care treatment for patients suffering with SCLC (small cell lung cancer) as well as other neuroendocrine cancers. The acquired drug discovery platform is also expected to add multiple targeted solid tumor therapies to AbbVie’s portfolio in the future.

AbbVie’s Rova-T: Solid Growth Driver for the Future?

The above diagram shows the total deaths attributable to various neuroendocrine cancers in the United States in 2017. The diagram also shows a breakdown of mortalities attributable to various types of lung cancers in 2017.

Rova-T strategy

AbbVie expects data in 2Q18 from TRINITY, its open-label, single-arm study evaluating Rova-T, a DLL3 (delta-like protein 3)-targeted antibody-drug conjugate (or ADC), in patients suffering with relapsed/refractory (or R/R) SCLC and expressing a high level of DLL3. Based on data from this registrational trial, AbbVie plans to file an NDA (New Drug Application) with the FDA (U.S. Food & Drug Administration) for Rova-T in the third line plus SCLC indication.

AbbVie aims to rapidly advance Rova-T in the R/R SCLC indication from 2018 to 2020. Besides TRINITY, the company is also recruiting patients in the TAHOE study to compare Rova-T with topotecan, the only FDA-approved therapy for relapsed SCLC, as a second-line therapy for advanced or metastatic SCLC patients. These patients also express a high level of DLL3 protein. AbbVie thus aims to advance the solid tumor treatment paradigm by creating an awareness about targeting tumor-initiating cells and positioning the DLL3 protein as a major solid tumor biomarker. Rova-T is thus expected to enable AbbVie to compete aggressively with other biomarker-based solid tumor players such as Pfizer (PFE), Bristol-Myers Squibb (BMY), and Merck & Co. (MRK).

AbbVie accounts for 1.4% of the Vanguard Growth ETF (VUG).

In the next part, let’s take a look at the market opportunity for Rova-T in the SCLC segment.

Latest articles

23 May

Trade War Subdues Manufacturing PMIs around the World

WRITTEN BY Mayur Sontakke, CFA, FRM

Today, IHS Markit published its purchasing managers' indexes or PMIs for May countries around the world.

Best Buy (BBY) reported better-than-expected earnings for the first quarter of fiscal 2020, which ended on May 4.

23 May

Why Apple Stock Is Down 2.7% Today

WRITTEN BY John Parker

On May 23 at 12:46 PM EDT, Apple (AAPL) was trading at $179.12 with a 2.0% loss for the day.

The CBOE Volatility Index has been sitting at very low levels for most of 2019.

23 May

Cannabis Stocks Fell Due to Trade Fears

WRITTEN BY Adam Jones

On May 23, CannTrust (CTST) was trading nearly 4.1% lower, while Cronos Group (CRON) fell 3.3%.

US equity markets are in the red today amid the escalation in the US-China trade war.

172.31.16.229